Buspirone (Buspar ®)

What special precautions should I follow?

Before taking buspirone, tell your doctor and pharmacist if you are allergic to buspirone, any other medications, or any of the ingredients in buspirone tablets. Ask your pharmacist for a list of the ingredients. Tell your doctor if you are taking a monoamine oxidase (MAO) inhibitor such as isocarboxazid (Marplan), linezolid (Zyvox), methylene blue, phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar), and tranylcypromine (Parnate), or if you have stopped taking an MAO inhibitor within the past 14 days. Your doctor will probably tell you not to take buspirone. If you stop taking buspirone, you should wait at least 14 days before you start to take an MAO inhibitor. Tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: anticonvulsants such as carbamazepine (Tegretol), phenobarbital, and phenytoin (Dilantin, Phenytek); dexamethasone; diazepam (Valium); diltiazem (Cardizem, Dilacor, Tiazac); erythromycin (E.E.S., E-Mycin, Erythrocin, others); haloperidol (Haldol); ketoconazole; itraconazole (Onmel, Sporanox); medications for migraine headaches such as almotriptan (Axert), eletriptan (Relpax), frovatriptan (Frova), naratriptan (Amerge), rizatriptan (Maxalt), sumatriptan (Imitrex), and zolmitriptan (Zomig); muscle relaxants; nefazodone (Serzone); pain medications or narcotics; rifampin (Rifadin, Rimactane); ritonavir (Norvir); sedatives; selective serotonin-reuptake inhibitors such as citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem, Selfemra), fluvoxamine (Luvox), paroxetine (Brisdelle, Paxil, Pexeva), and sertraline (Zoloft); serotonin–norepinephrine reuptake inhibitors (SNRI) such as desvenlafaxine (Khedezla, Pristiq), duloxetine (Cymbalta), levomilnacipran (Fetzima), milnacipran (Savella), and venlafaxine (Effexor); sleeping pills; tranquilizers; trazodone (Desyrel); and verapamil (Calan, Covera, Verelan). Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with buspirone, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.​​ E-Mycin, Erythrocin, otros); haloperidol (Haldol); ketoconazol; itraconazol (Onmel, Sporanox); medicamentos para las migrañas como almotriptán (Axert), eletriptán (Relpax), frovatriptán (Frova), naratriptán (Amerge), rizatriptán (Maxalt), sumatriptán (Imitrex) y zolmitriptán (Zomig); relajantes musculares; nefazodona (Serzone); analgésicos o narcóticos; rifampicina (Rifadin, Rimactane); ritonavir (Norvir); sedantes; inhibidores selectivos de la recaptación de serotonina como citalopram (Celexa), escitalopram (Lexapro), fluoxetina (Prozac, Sarafem, Selfemra), fluvoxamina (Luvox), paroxetina (Brisdelle, Paxil, Pexeva) y sertralina (Zoloft); inhibidores de la recaptación de serotonina y norepinefrina (IRSN) como desvenlafaxina (Khedezla, Pristiq), duloxetina (Cymbalta), levomilnacipran (Fetzima), milnacipran (Savella) y venlafaxina (Effexor); pastillas para dormir; tranquilizantes; trazodona (Desyrel); y verapamilo (Calan, Covera, Verelan). Es posible que su médico necesite cambiar las dosis de sus medicamentos o monitorearlo cuidadosamente para detectar efectos secundarios. Muchos otros medicamentos también pueden interactuar con la buspirona, así que asegúrese de informarle a su médico sobre todos los medicamentos que está tomando, incluso los que no aparecen en esta lista.

Informe a su médico si tiene o alguna vez ha tenido una enfermedad renal o hepática o antecedentes de abuso de alcohol o drogas. Informe a su médico si está embarazada, planea quedar embarazada o está amamantando. Si queda embarazada mientras toma buspirona, llame a su médico. Si va a someterse a una cirugía, incluida una cirugía dental, informe a su médico o dentista que está tomando buspirona. Debe saber que este medicamento puede provocarle somnolencia. No conduzca un automóvil ni opere maquinaria hasta que sepa cómo le afecta este medicamento. Recuerde que el alcohol puede aumentar la somnolencia causada por este medicamento. No beba alcohol mientras toma buspirona.

¿Qué efectos secundarios puede causar este medicamento?

La buspirona puede ocasionar efectos secundarios. Informe a su médico si alguno de estos síntomas es grave o no desaparece:

• dizziness
  

• nausea
  

• diarrhea​

• headache
  

• excitement
  

• confusion
  

• fatigue
  

• nervousness
  

• difficulty falling asleep or staying asleep
  

• feelings of anger or hostility​​

• lightheadedness​​
• headache​​
• weakness​
• numbness​​
• increased sweating
  

Algunos efectos colaterales pueden ser serios. Si experimenta alguno de estos síntomas, llame a su médico de inmediato:

• rash
  
• hives
  
• itching
  
• swelling of the face, eyes, mouth, throat, tongue, or lips
  
• fast or irregular heartbeat​​
• blurred vision​​
• uncontrollable shaking of a part of the body​​
• agitation, fever, sweating, dizziness, flushing, confusion, fast or irregular heartbeat, shivering, severe muscle stiffness or twitching, seizures, hallucinations, loss of coordination, nausea, vomiting, or diarrhea
  

Si experimenta un efecto secundario grave, usted o su médico pueden enviar un informe al programa MedWatch Adverse Event Reporting de la Administración de Alimentos y Medicamentos (FDA) online () o por teléfono (1-800-332-1088).

En caso de emergencia/sobredosis

En caso de sobredosis, llame a la línea de ayuda de control de intoxicaciones al 1-800-222-1222. La información también está disponible en línea en https://www.poisonhelp.org/help. Si la víctima se derrumbó, tuvo una convulsión, tiene problemas para respirar o no puede despertarse, llame inmediatamente a los servicios de emergencia al 911.

Los síntomas de una sobredosis pueden incluir náuseas, vómitos, mareos, somnolencia, visión borrosa o malestar estomacal.

Referencia: https://medlineplus.gov/druginfo/meds/a688005.html

Fluoxetine (Prozac ®)

IMPORTANT WARNING:

A small number of children, teenagers, and young adults (up to 24 years of age) who took antidepressants ('mood elevators') such as fluoxetine during clinical studies became suicidal (thinking about harming or killing oneself or planning or trying to do so). Children, teenagers, and young adults who take antidepressants to treat depression or other mental illnesses may be more likely to become suicidal than children, teenagers, and young adults who do not take antidepressants to treat these conditions. However, experts are not sure about how great this risk is and how much it should be considered in deciding whether a child or teenager should take an antidepressant.

Debe saber que su salud mental puede cambiar de manera inesperada cuando toma fluoxetina u otros antidepresivos, incluso si es un adulto mayor de 24 años. Puede tener tendencias suicidas, especialmente al comienzo de su tratamiento y en cualquier momento en que aumente o disminuya su dosis. Usted, su familia o su cuidador deben llamar a su médico de inmediato si experimenta alguno de los siguientes síntomas: depresión nueva o que empeora; pensar en lastimarse o suicidarse, o planear o intentar hacerlo; preocupación extrema; agitación; ataques de pánico; dificultad para conciliar el sueño o permanecer dormido; comportamiento agresivo; irritabilidad; actuar sin pensar; inquietud severa; y frenética excitación anormal. Asegúrese de que su familia o cuidador sepa qué síntomas pueden ser graves para que puedan llamar al médico si no puede buscar tratamiento por su cuenta. Su proveedor de atención médica querrá verlo con frecuencia mientras esté tomando fluoxetina, especialmente al comienzo de su tratamiento. Asegúrese de asistir a todas las citas para las visitas al consultorio con su médico.

El médico o farmacéutico le dará la hoja de información del fabricante para el paciente (Guía del medicamento) cuando comience el tratamiento con fluoxetina. Lea atentamente la información y consulte a su médico o farmacéutico si tiene alguna duda. También puede obtener la Guía del medicamento en el sitio web de la FDA: http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm.

No matter your age, before you take an antidepressant, you, your parent, or your caregiver should talk to your doctor about the risks and benefits of treating your condition with an antidepressant or with other treatments. You should also talk about the risks and benefits of not treating your condition. You should know that having depression or another mental illness greatly increases the risk that you will become suicidal. This risk is higher if you or anyone in your family has or has ever had bipolar disorder (mood that changes from depressed to abnormally excited) or mania (frenzied, abnormally excited mood) or has thought about or attempted suicide. Talk to your doctor about your condition, symptoms, and personal and family medical history. You and your doctor will decide what type of treatment is right for you.

What special precautions should I follow?

Before taking fluoxetine, tell your doctor and pharmacist if you are allergic to fluoxetine, any other medications, or any of the ingredients in fluoxetine capsules, tablets, or solution. Ask your pharmacist for a list of the ingredients. Tell your doctor if you are taking pimozide (Orap), thioridazine, or a monoamine oxidase (MAO) inhibitor such as isocarboxazid (Marplan), linezolid (Zyvox), methylene blue, phenelzine (Nardil), selegiline (Emsam, Zelapar), and tranylcypromine (Parnate), or if you have stopped taking a monoamine oxidase inhibitor within the past 2 weeks. Your doctor will probably tell you that you should not take fluoxetine. If you stop taking fluoxetine, you should wait at least 5 weeks before you begin to take thioridazine or a monoamine oxidase inhibitor. Tell your doctor and pharmacist what other prescription and nonprescription medications and vitamins you are taking or plan to take. Be sure to mention any of the following: alprazolam (Xanax); amiodarone (Pacerone, Nexterone); certain antibiotics such as erythromycin (E.E.S, Eryc, Ery-tab), gatifloxacin, moxifloxacin (Avelox), and sparfloxacin (no longer available in U.S., Zagam); amphetamines such as amphetamine (in Adderall), dextroamphetamine (Dexedrine, Dextrostat, in Adderall), and methamphetamine (Desoxyn); anticoagulants ('blood thinners') such as warfarin (Coumadin, Jantoven); antidepressants (mood elevators) such as amitriptyline, amoxapine, clomipramine (Anafranil), desipramine (Norpramin), doxepin, imipramine (Tofranil), nortriptyline (Pamelor), protriptyline, and trimipramine; aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen (Advil, Motrin) and naproxen (Aleve, Naprosyn); buspirone; clopidogrel (Plavix); diazepam (Valium, Valtoco); digoxin (Lanoxin); diuretics ('water pills'); dolasetron (Anzemet); fentanyl (Fentora, Lazanda, Subsys, others); flecainide; insulin or oral medications for diabetes; lithium (Lithobid); medications for anxiety and Parkinson's disease; medications for mental illness such as chlorpromazine, clozapine (Clozaril, Versacloz), droperidol (Inapsine), haloperidol (Haldol), iloperidone (Fanapt), and ziprasidone (Geodon); methadone (Methadose); medications for migraine headaches such as almotriptan, eletriptan (Relpax), frovatriptan (Frova), naratriptan (Amerge), rizatriptan (Maxalt), sumatriptan (Imitrex), and zolmitriptan (Zomig); pentamidine (Pentam); quinidine (in Nuedexta); procainamide; medications for seizures such as carbamazepine (Epitol, Equetro, Tegretol, Teril) and phenytoin (Dilantin, Phenytek); sedatives; sleeping pills; other selective serotonin-reuptake inhibitors such as citalopram (Celexa), or fluvoxamine (Luvox), paroxetine (Paxil), or sertraline (Zoloft); serotonin–norepinephrine reuptake inhibitors (SNRI) medications desvenlafaxine (Khedezla, Pristiq), duloxetine (Cymbalta), levomilnacipran (Fetzima), and venlafaxine; sotalol (Betapace, Sorine); tramadol (Conzip, Qdolo, Ultram, in Ultracet); tranquilizers; and vinblastine. Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Tell your doctor what nutritional supplements and herbal products you are taking, especially products that contain St. John's wort or tryptophan.​

Tell your doctor if you or anyone in your family has or has ever had a prolonged QT interval (a rare heart problem that may cause irregular heartbeat, fainting, or sudden death). Also tell your doctor if you have a low level of potassium, magnesium, or sodium in your blood or are being treated with electroshock therapy (procedure in which small electric shocks are administered to the brain to treat certain mental illnesses). Tell your doctor if you have recently had a heart attack and if you have or have ever had a slow or irregular heartbeat, heart failure, or any other heart problems; high blood pressure; bleeding problems; a stroke; diabetes; seizures; or liver or kidney disease.

Tell your doctor if you are pregnant, especially if you are in the last few months of your pregnancy, or if you plan to become pregnant or are breastfeeding. If you become pregnant while taking fluoxetine, call your doctor. Fluoxetine may cause problems in newborns following delivery if it is taken during the last months of pregnancy. You should know that fluoxetine may make you drowsy and may affect your judgment, thinking, and movements. Do not drive a car or operate machinery until you know how this medication affects you.

Remember that alcohol can add to the drowsiness caused by this medication. You should know that fluoxetine may cause angle-closure glaucoma (a condition where the fluid is suddenly blocked and unable to flow out of the eye causing a quick, severe increase in eye pressure which may lead to a loss of vision). Talk to your doctor about having an eye examination before you start taking this medication. If you have nausea, eye pain, changes in vision, such as seeing colored rings around lights, and swelling or redness in or around the eye, call your doctor or get emergency medical treatment right away.

What side effects can this medication cause?

Fluoxetine may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

• nervousness
  
• anxiety
  
• difficulty falling asleep or staying asleep
  
• nausea
  
• diarrhea
  
• dry mouth​​
• heartburn​​
• yawning​​
• weakness​
• uncontrollable shaking of a part of the body​​
• decreased appetite​
• weight loss​​
• unusual dreams​​
• stuffy nose​​
• sexual problems in males; decreased sex drive, inability to get or keep an erection, or delayed or absent ejaculation​​
• sexual problems in females; decreased sex drive, or delayed orgasm or unable to have an orgasm​​
• excessive sweating​
• headache, confusion, weakness, difficulty concentrating, or memory problems
  
  

Some side effects can be serious. If you experience any of the following symptoms or those listed in the IMPORTANT WARNING or SPECIAL PRECAUTIONS section, call your doctor immediately:

• nervousness
  
• anxiety
  
• difficulty falling asleep or staying asleep
  
• nausea​​
• rash​​
• hives or blisters​​
• itching​
• fever​
• joint pain​
• swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs​​
• difficulty breathing or swallowing​​
• agitation, fever, sweating, confusion, fast or irregular heartbeat, shivering, severe muscle stiffness or twitching, hallucinations, loss of coordination, nausea, vomiting, or diarrhea​​
• fast, slow, or irregular heartbeat​​
• shortness of breath​​
• dizziness or fainting​​
• seizures​​
• abnormal bleeding or bruising
  

Fluoxetine may decrease appetite and cause weight loss in children. Your child's doctor will watch his or her growth carefully. Talk to your child's doctor if you have concerns about your child's growth or weight while he or she is taking this medication. Talk to your child's doctor about the risks of giving fluoxetine to your child. Fluoxetine may cause other side effects. Call your doctor if you have any unusual problems while taking this medication. If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

In case of emergency/overdose

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Symptoms of overdose may include unsteadiness, confusion, unresponsiveness, nervousness, uncontrollable shaking of a part of the body, dizziness, rapid, irregular, or pounding heartbeat, seeing things or hearing voices that do not exist (hallucinating), fever, fainting, seizures, coma (loss of consciousness for a period of time).


Reference: https://medlineplus.gov/druginfo/meds/a689006.html

Escitalopram (Lexapro ®)

IMPORTANT WARNING:

A small number of children, teenagers, and young adults (up to 24 years of age) who took antidepressants ('mood elevators') such as escitalopram during clinical studies became suicidal (thinking about harming or killing oneself or planning or trying to do so). Children, teenagers, and young adults who take antidepressants to treat depression or other mental illnesses may be more likely to become suicidal than children, teenagers, and young adults who do not take antidepressants to treat these conditions. However, experts are not sure about how great this risk is and how much it should be considered in deciding whether a child or teenager should take an antidepressant. Children younger than 12 years of age should not normally take escitalopram, but in some cases, a doctor may decide that escitalopram is the best medication to treat a child's condition.

You should know that your mental health may change in unexpected ways when you take escitalopram or other antidepressants even if you are an adult over 24 years of age. You may become suicidal, especially at the beginning of your treatment and any time that your dose is increased or decreased. You, your family, or your caregiver should call your doctor right away if you experience any of the following symptoms: new or worsening depression; thinking about harming or killing yourself, or planning or trying to do so; extreme worry; agitation; panic attacks; difficulty falling asleep or staying asleep; aggressive behavior; irritability; acting without thinking; severe restlessness; and frenzied abnormal excitement. Be sure that your family or caregiver knows which symptoms may be serious so they can call the doctor if you are unable to seek treatment on your own. Your healthcare provider will want to see you often while you are taking escitalopram, especially at the beginning of your treatment. Be sure to keep all appointments for office visits with your doctor.

The doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with escitalopram. Read the information carefully and ask your doctor or pharmacist if you have any questions. You also can obtain the Medication Guide from the FDA website: http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm.

No matter your age, before you take an antidepressant, you, your parent, or your caregiver should talk to your doctor about the risks and benefits of treating your condition with an antidepressant or with other treatments. You should also talk about the risks and benefits of not treating your condition. You should know that having depression or another mental illness greatly increases the risk that you will become suicidal. Tell your doctor if you or anyone in your family has or has ever had bipolar disorder (mood that changes from depressed to abnormally excited) or mania (frenzied, abnormally excited mood) or has thought about or attempted suicide. Talk to your doctor about your condition, symptoms, and personal and family medical history. You and your doctor will decide what type of treatment is right for you.​​

What special precautions should I follow?

Before taking escitalopram, tell your doctor or pharmacist if you are allergic to escitalopram, citalopram (Celexa), any other medications, or any of the ingredients in the tablets or solution. Ask your pharmacist or check the Medication Guide for a list of the ingredients. Tell your doctor if you are taking pimozide (Orap) or a monoamine oxidase (MAO) inhibitor such as isocarboxazid (Marplan), linezolid (Zyvox), methylene blue, phenelzine (Nardil), selegiline (Emsam, Zelapar), and tranylcypromine (Parnate), or if you have stopped taking an MAO inhibitor within the past 14 days. Your doctor will probably tell you not to take escitalopram. If you stop taking escitalopram, you should wait at least 14 days before you start to take an MAO inhibitor. You should know that escitalopram is very similar to another SSRI, citalopram (Celexa). You should not take these two medications together. Tell your doctor or pharmacist what prescription and nonprescription medications and vitamins you are taking or plan to take. Be sure to mention any of the following: anticoagulants ('blood thinners') such as warfarin (Coumadin, Jantoven); amphetamines such as amphetamine (in Adderall, in Mydayis), dextroamphetamine (Dexedrine, in Adderall), and methamphetamine (Desoxyn); aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen (Advil, Motrin) and naproxen (Aleve, Naprosyn); buspirone; carbamazepine (Carbatrol, Equetro, Tegretol, others); cimetidine (Tagamet); diuretics ('water pills'); fentanyl (Actiq, Duragesic, Fentora, Subsys); ketoconazole (Sporanox); lithium (Lithobid); medications for anxiety, mental illness, or seizures; medications for migraine headaches such as almotriptan, eletriptan (Relpax), frovatriptan (Frova), naratriptan (Amerge), rizatriptan (Maxalt), sumatriptan (Imitrex, Tosymra, in Treximet), and zolmitriptan (Zomig); metoprolol (Lopressor, Toprol XL); other SSRIs such as fluoxetine (Prozac, in Symbyax), fluvoxamine (Luvox), paroxetine (Paxil), and sertraline (Zoloft); serotonin–norepinephrine reuptake inhibitors (SNRI) such as duloxetine (Cymbalta); sedatives; sleeping pills; tramadol (Conzip, Qdolo, Ultram, in Ultracet); tranquilizers; and tricyclic antidepressants such as amitriptyline, amoxapine, clomipramine (Anafranil), desipramine (Norpramin), doxepin (Silenor), imipramine (Tofranil), nortriptyline (Pamelor), protriptyline, and trimipramine. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

Tell your doctor what nutritional supplements and herbal products you are taking, especially products containing St. John's wort or tryptophan. Tell your doctor if you have a low level of sodium in your blood, if you drink or have ever drunk large amounts of alcohol, or use or have ever used street drugs or have ever overused prescription medications. Also tell your doctor if you have recently had a heart attack and if you have or have ever had high blood pressure; a stroke; bleeding problems; seizures; or liver, kidney, or heart disease. Tell your doctor if you are pregnant, especially if you are in the last few months of your pregnancy, or if you plan to become pregnant or are breast-feeding. If you become pregnant while taking escitalopram, call your doctor. Escitalopram may cause problems in newborns following delivery if it is taken during the last months of pregnancy. If You are having surgery, including dental surgery, tell the doctor or dentist that you are taking escitalopram. You should know that escitalopram may make you drowsy and may affect your judgment, thinking, and movements. Do not drive a car or operate machinery until you know how this medication affects you. Remember that alcohol can add to the drowsiness caused by this medication. You should know that escitalopram may cause angle-closure glaucoma (a condition where the fluid is suddenly blocked and unable to flow out of the eye causing a quick, severe increase in eye pressure which may lead to a loss of vision). Talk to your doctor about having an eye examination before you start taking this medication. If you have nausea, eye pain, changes in vision, such as seeing colored rings around lights, and swelling or redness in or around the eye, call your doctor or get emergency medical treatment right away.

What side effects can this medication cause?

Escitalopram may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

• nausea
  
• diarrhea
  
• constipation
  
• sexual problems in males; decreased sex drive, inability to get or keep an erection, or delayed or absent ejaculation​​
• sexual problems in females; decreased sex drive, or delayed orgasm or unable to have an orgasm​​
• drowsiness​​
• yawning​​
• shaking​
• difficulty falling asleep or staying asleep​​
• increased sweating​
• dizziness​​
• heartburn​​
• stomach pain​
• excessive tiredness​
• dry mouth​​
• decreased appetite​​​
• weight loss​​
• flu-like symptoms​
• runny nose​
• sneezing
  

Some side effects can be serious. If you experience either of the following symptoms or those listed in the IMPORTANT WARNING or SPECIAL PRECAUTIONS sections, call your doctor immediately:

• unusual excitement
  
• seeing things or hearing voices that do not exist (hallucinating)
  
• rash
  
• hives or blisters​​
• itching​
• fever​
• joint pain​
• difficulty breathing or swallowing​​
• swelling of the face, throat, tongue, lips, or eyes​​
• fever, sweating, confusion, fast or irregular heartbeat, severe muscle stiffness or twitching, agitation, hallucinations, loss of coordination, nausea, vomiting, or diarrhea​​
• abnormal bleeding or bruising​​
• nose bleeding​
• headache​​
• unsteadiness​​
• problems with thinking, concentration, or memory​​
• seizures​​
• difficult or painful urination
  

Escitalopram may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch

In case of emergency/overdose

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Symptoms of overdose may include dizziness, nausea, vomiting, drowsiness, fast or pounding heartbeat, seizures, or coma (loss of consciousness for a period of time).

Reference: https://medlineplus.gov/druginfo/meds/a603005.html

Bupropion (Wellbutrin ® XL)

IMPORTANT WARNING:

For people taking bupropion (Wellbutrin) for depression:

A small number of children, teenagers, and young adults (up to 24 years of age) who took antidepressants ('mood elevators') such as bupropion during clinical studies became suicidal (thinking about harming or killing oneself or planning or trying to do so). Children, teenagers, and young adults who take antidepressants to treat depression or other mental illnesses may be more likely to become suicidal than children, teenagers, and young adults who do not take antidepressants to treat these conditions. This risk should be considered and compared with the potential benefit in the treatment of depression, in deciding whether a child or teenager should take an antidepressant. Children younger than 18 years of age should not normally take bupropion, but in some cases, a doctor may decide that bupropion is the best medication to treat a child's condition. No matter what your age, before you take an antidepressant, you, your parent, or your caregiver should talk to your doctor about the risks and benefits of treating your condition with an antidepressant or with other treatments. You should also talk about the risks and benefits of not treating your condition. You should know that having depression or another mental illness greatly increases the risk that you will become suicidal, especially at the beginning of your treatment or any time that your dose is increased or decreased. This risk is higher if you or anyone in your family has or has ever had bipolar disorder or mania or has thought about or attempted suicide. Talk to your doctor about your condition, symptoms, and personal and family medical history. You and your doctor will decide what type of treatment is right for you.

You should know that your mental health may change in unexpected ways when you take bupropion or other antidepressants even if you are an adult over age 24 or if you do not have a mental illness and you are taking bupropion to treat a different type of condition. You may become suicidal, especially at the beginning of your treatment and any time that your dose is increased or decreased. You, your family, or your caregiver should call your doctor right away if you experience any of the following symptoms: new or worsening depression; thinking about harming or killing yourself, or planning or trying to do so; extreme worry; agitation; panic attacks; difficulty falling asleep or staying asleep; aggressive behavior; irritability; acting without thinking; severe restlessness; and frenzied abnormal excitement. Be sure that your family or caregiver knows which symptoms may be serious so they can call the doctor if you are unable to seek treatment on your own.

For all patients taking bupropion:

Your health care provider will want to see you often while you are taking bupropion, especially at the beginning of your treatment. Be sure to keep all appointments or office visits with your doctor. Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with bupropion and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You also can visit the Food and Drug Administration (FDA) website: http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm or the manufacturer's website to obtain the Medication Guide. Talk to your doctor about the risks and benefits of taking bupropion.

What special precautions should I follow?

Before taking bupropion, tell your doctor and pharmacist if you are allergic to bupropion, any other medications, or any of the ingredients in bupropion tablets. Ask your pharmacist or check the Medication Guide for a list of the ingredients. Tell your doctor if you are taking a monoamine oxidase (MAO) inhibitor such as isocarboxazid (Marplan), linezolid (Zyvox), methylene blue, phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar), and tranylcypromine (Parnate), or if you have stopped taking an MAO inhibitor within the past 14 days. Your doctor will probably tell you not to take bupropion. Do not take more than one product containing bupropion at a time. You could receive too much medication and experience severe side effects. Tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: amantadine (Symmetrel); beta blockers such as atenolol (Tenormin), labetalol (Normodyne), metoprolol (Lopressor, Toprol XL), nadolol (Corgard), and propranolol (Inderal); cimetidine (Tagamet); clopidogrel (Plavix); cyclophosphamide (Cytoxan, Neosar); efavirenz (Sustiva, in Atripla); insulin or oral medications for diabetes; medications for irregular heartbeat such as flecainide (Tambocor) and propafenone (Rythmol); medications for mental illness such as haloperidol (Haldol), risperidone (Risperdal), and thioridazine (Mellaril); medications for seizures such as carbamazepine (Tegretol), phenobarbital (Luminal, Solfoton), and phenytoin (Dilantin); levodopa (Sinemet, Larodopa); lopinavir and ritonavir (Kaletra); nelfinavir (Viracept); nicotine patch; oral steroids such as dexamethasone (Decadron, Dexone), methylprednisolone (Medrol), and prednisone (Deltasone); orphenadrine (Norflex); other antidepressants such as citalopram (Celexa), desipramine (Norpramin), fluoxetine (Prozac, Sarafem, in Symbyax), fluvoxamine (Luvox), imipramine (Tofranil), nortriptyline (Aventyl, Pamelor), paroxetine (Paxil) and sertraline (Zoloft); ritonavir (Norvir); sedatives; sleeping pills; tamoxifen (Nolvadex, Soltamox); theophylline (Theobid, Theo-Dur, others); thiotepa; and ticlopidine (Ticlid). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

Tell your doctor if you have or have ever had seizures, anorexia nervosa (an eating disorder) or bulimia (an eating disorder). Also tell your doctor if you drink large amounts of alcohol but expect to suddenly stop drinking or you take sedatives but expect to suddenly stop taking them. Your doctor will probably tell you not to take bupropion. Tell your doctor if you drink large amounts of alcohol, use street drugs, or overuse prescription medications and if you have ever had a heart attack; a head injury; a tumor in your brain or spine; high blood pressure; diabetes; or liver, kidney, or heart disease. Tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking bupropion, call your doctor. You should know that bupropion may make you drowsy. Do not drive a car or operate machinery until you know how this medication affects you. Talk to your doctor about the safe use of alcoholic beverages while you are taking bupropion. Alcohol can make the side effects from bupropion worse. You should know that bupropion may cause an increase in your blood pressure. Your doctor may check your blood pressure before starting treatment and regularly while you are taking this medication, especially if you also are using nicotine replacement therapy. You should know that bupropion may cause angle-closure glaucoma (a condition where the fluid is suddenly blocked and unable to flow out of the eye causing a quick, severe increase in eye pressure which may lead to a loss of vision). Talk to your doctor about having an eye examination before you start taking this medication. If you have nausea, eye pain, changes in vision, such as seeing colored rings around lights, and swelling or redness in or around the eye, call your doctor or get emergency medical treatment right away.

You should know that some people have reported symptoms such as changes in behavior, hostility, agitation, depressed mood, and suicidal thoughts (thinking about harming or killing oneself or planning or trying to do so) while taking bupropion to stop smoking. The role of bupropion in causing these mood changes is unclear since people who quit smoking with or without medication may experience changes in their mental health due to nicotine withdrawal. However, some of these symptoms occurred in people who were taking bupropion and continued to smoke. Some people had these symptoms when they began taking bupropion, and others developed them after several weeks of treatment or after stopping bupropion. These symptoms have occurred in people without a history of mental illness and have worsened in people who already had a mental illness. Tell your doctor if you have or have ever had depression, bipolar disorder (mood that changes from depressed to abnormally excited), schizophrenia (a mental illness that causes disturbed or unusual thinking, loss of interest in life, and strong or inappropriate emotions), or other mental illnesses. If you experience any of the following symptoms, stop taking bupropion (Zyban) and call your doctor immediately: suicidal thoughts or actions; new or worsening depression, anxiety, or panic attacks; agitation; restlessness; angry or violent behavior; acting dangerously; mania (frenzied, abnormally excited or irritated mood); abnormal thoughts or sensations; hallucinations (seeing things or hearing voices that do not exist); feeling that people are against you; feeling confused; or any other sudden or unusual changes in behavior. Be sure that your family or caregiver knows which symptoms may be serious so they can call the doctor if you are unable to seek treatment on your own. Your doctor will monitor you closely until your symptoms get better.

What side effects can this medication cause?

Bupropion may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

• drowsiness
  
• anxiety
  
• excitement
  
• difficulty falling asleep or staying asleep​​
• dry mouth​​
• dizziness​​
• headache​​
• nausea​​
• vomiting​​
• stomach pain​
• uncontrollable shaking of a part of the body​​
• decreased appetite​
• weight loss​​
• constipation​
• excessive sweating​
• ringing in ears​​
• changes in your sense of taste​​
• frequent urination​​
• sore throat
  

Some side effects can be serious. If you experience any of the following symptoms or those listed in the IMPORTANT WARNING or SPECIAL PRECAUTIONS sections, call your doctor immediately or get emergency medical treatment:

• seizures
  
• confusion
  
• hallucinating (seeing things or hearing voices that do not exist)
  
• irrational fears​​
• muscle or joint pain​
• rapid, pounding, or irregular heartbeat
  

If you experience any of the following symptoms, stop taking bupropion and call your doctor immediately or get emergency medical treatment:

• fever
  
• rash or blisters
  
• itching​
• hives​​
• swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs​​
• hoarseness​​
• difficulty breathing or swallowing​​
• chest pain
  

Bupropion may cause other side effects. Call your doctor if you have any unusual problems while taking this medication. If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

In case of emergency/overdose

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Symptoms of overdose may include seizure, hallucinating (seeing things or hearing voices that do not exist), loss of consciousness, or rapid or pounding heartbeat.

Reference: https://medlineplus.gov/druginfo/meds/a695033.html

Venlafaxine (Effexor ® XR)

IMPORTANT WARNING:

A small number of children, teenagers, and young adults (up to 24 years of age) who took antidepressants ('mood elevators') such as venlafaxine during clinical studies became suicidal (thinking about harming or killing oneself or planning or trying to do so). Children, teenagers, and young adults who take antidepressants to treat depression or other mental illnesses may be more likely to become suicidal than children, teenagers, and young adults who do not take antidepressants to treat these conditions. However, experts are not sure about how great this risk is and how much it should be considered in deciding whether a child or teenager should take an antidepressant. Children younger than 18 years of age should not normally take venlafaxine, but in some cases, a doctor may decide that venlafaxine is the best medication to treat a child's condition.

You should know that your mental health may change in unexpected ways when you take venlafaxine or other antidepressants even if you are an adult over 24 years of age. You may become suicidal, especially at the beginning of your treatment and any time that your dose is increased or decreased. You, your family, or your caregiver should call your doctor right away if you experience any of the following symptoms: new or worsening depression; thinking about harming or killing yourself, or planning or trying to do so; extreme worry; agitation; panic attacks; difficulty falling asleep or staying asleep; aggressive behavior; irritability; acting without thinking; severe restlessness; and frenzied abnormal excitement. Be sure that your family or caregiver knows which symptoms may be serious so they can call the doctor if you are unable to seek treatment on your own. Your healthcare provider will want to see you often while you are taking venlafaxine, especially at the beginning of your treatment. Be sure to keep all appointments for office visits with your doctor.
 
The doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with venlafaxine. Read the information carefully and ask your doctor or pharmacist if you have any questions. You also can obtain the Medication Guide from the FDA website: http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm.

No matter your age, before you take an antidepressant, you, your parent, or your caregiver should talk to your doctor about the risks and benefits of treating your condition with an antidepressant or with other treatments. You should also talk about the risks and benefits of not treating your condition. You should know that having depression or another mental illness greatly increases the risk that you will become suicidal. This risk is higher if you or anyone in your family has or has ever had bipolar disorder (mood that changes from depressed to abnormally excited) or mania (frenzied, abnormally excited mood) or has thought about or attempted suicide. Talk to your doctor about your condition, symptoms, and personal and family medical history. You and your doctor will decide what type of treatment is right for you.

What special precautions should I follow?

Before taking venlafaxine, tell your doctor and pharmacist if you are allergic to venlafaxine, any other medications, or any of the ingredients in venlafaxine tablets or extended-release capsules. Ask your pharmacist for a list of the ingredients. You should know that desvenlafaxine is very similar to another SNRI, desvenlafaxine (Pristiq). You should not take these medications together. Tell your doctor if you are taking a monoamine oxidase (MAO) inhibitor, such as isocarboxazid (Marplan), linezolid (Zyvox), methylene blue, phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar), and tranylcypromine (Parnate), or if you have stopped taking one of these medications within the past 14 days. Your doctor will probably tell you that you should not take venlafaxine. If you stop taking venlafaxine, your doctor will tell you that you should wait at least 7 days before you start to take an MAO inhibitor. Tell your doctor and pharmacist what other prescription and nonprescription medications, and vitamins you are taking or plan to take. Be sure to mention any of the following: amphetamines such as amphetamine (in Adderall, in Mydayis), dextroamphetamine (Dexedrine, in Adderall), and methamphetamine (Desoxyn); anticoagulants ('blood thinners') such as warfarin (Coumadin, Jantoven); aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen (Advil, Motrin) and naproxen (Aleve, Naprosyn); buspirone; cimetidine (Tagamet); clozapine (Clozaril); diuretics ('water pills'); fentanyl (Actiq, Duragesic, Fentora, Subsys); haloperidol (Haldol); indinavir (Crixivan); ketoconazole; lithium; medications for anxiety, mental illness, pain, seizures, or weight loss; medications for migraine such as almotriptan, eletriptan (Relpax), frovatriptan (Frova), naratriptan (Amerge), rizatriptan (Maxalt), sumatriptan (Imitrex), and zolmitriptan (Zomig); metoprolol (Kapspargo Sprinkle, Lopressor, Toprol); mirtazapine (Remeron); phentermine (Adipex P, Lomaira, Qsymia); sedatives; selective serotonin reuptake inhibitors (SSRIs) such as citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac, in Symbyax), fluvoxamine (Luvox), paroxetine (Paxil), and sertraline (Zoloft); other SNRIs such as duloxetine (Cymbalta); sleeping pills; tramadol (Conzip, Qdola, Ultram in Ultracet); tranquilizers, and tricyclic antidepressants such as amitriptyline, amoxapine, clomipramine (Anafranil), desipramine (Norpramin), doxepin (Silenor), imipramine (Tofranil), nortriptyline (Pamelor), protriptyline, and trimipramine. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

Tell your doctor what nutritional supplements and herbal products you are taking, especially St. John's wort and tryptophan. Tell your doctor if you have ever used illegal drugs or overused prescription medications. Also tell your doctor if you have recently had a heart attack and if you have or have ever had high blood pressure, high blood cholesterol seizures, glaucoma (increased pressure in the eye that may cause loss of sight), or heart, kidney, liver, or thyroid disease. Tell your doctor if you are pregnant, especially if you are in the last few months of your pregnancy, or if you plan to become pregnant or are breast-feeding. If you become pregnant while taking venlafaxine, call your doctor. Venlafaxine may cause problems in newborns following delivery if it is taken during the last months of pregnancy. If you are having surgery, including dental surgery, tell the doctor or dentist that you are taking venlafaxine. You should know that this medication may make you drowsy and may affect your judgment, thinking, and movements. Do not drive a car or operate machinery until you know how this medication affects you. Remember that alcohol can add to the drowsiness caused by this medication. You should know that venlafaxine may cause high blood pressure. You should have your blood pressure checked before starting treatment and regularly while you are taking this medication. You should know that venlafaxine may cause angle-closure glaucoma (a condition where the fluid is suddenly blocked and unable to flow out of the eye causing a quick, severe increase in eye pressure which may lead to a loss of vision). Talk to your doctor about having an eye examination before you start taking this medication. If you have nausea, eye pain, changes in vision, such as seeing colored rings around lights, and swelling or redness in or around the eye, call your doctor or get emergency medical treatment right away.

What side effects can this medication cause?

Venlafaxine may cause side effects. Call your doctor if any of the following symptoms are severe or do not go away:

• drowsiness
  
• weakness or tiredness
  
• dizziness
  
• headache
  
• nightmares
  
• nausea​​
• vomiting​​
• stomach pain​
• constipation​
• diarrhea​
• gas
• heartburn​​
• burping​​
• dry mouth​​
• change in the ability to taste food​​
• decreased appetite​
• weight loss​​
• uncontrollable shaking of a part of the body​​
• pain, burning, numbness or tingling in a part of the body​
• yawning​​
• sweating​​
• hot flashes​​
• frequent urination​​
• difficult urination​
• sore throat, chills or other signs of infection​​
• ringing in ears​​
• sexual problems in males; decreased sex drive, inability to get or keep an erection, or delayed or absent ejaculation​​
• sexual problems in females; decreased sex drive, or delayed orgasm or unable to have an orgasm​​
• enlarged pupils (black circles in the middle of the eyes)
  

Some side effects can be serious. If you experience either of the following symptoms or those listed in the IMPORTANT WARNING or SPECIAL PRECAUTIONS sections, call your doctor immediately:

• rash
  
• hives
  
• itching
  
• difficulty breathing or swallowing
  
• chest pain​
• fast, pounding, or irregular heartbeat​
• seizures​​
• unusual bruising or bleeding​​
• small purple spots on the skin​​
• fever, sweating, confusion, fast or irregular heartbeat, severe muscle stiffness or twitching, agitation, hallucinations, loss of coordination, nausea, vomiting, or diarrhea​​
• problems with coordination​​
• hallucinating (seeing things or hearing voices that do not exist)​​
• coma (loss of consciousness for a period of time)
  

Venlafaxine may slow growth and weight gain in children. If your child is taking venlafaxine, your child's doctor will watch your child's growth carefully. Talk to your child's doctor about the risks of giving venlafaxine to your child. Venlafaxine may cause other side effects. Call your doctor if you have any unusual problems while you are taking this medication. If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

In case of emergency/overdose

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Symptoms of overdose may include dizziness, nausea, vomiting, burning, tingling, or numbness of the hands and feet, increased size of the pupil (black center of the eye), muscle pain, hot and cold spells, sleepiness, seizures, fast, slow, or irregular heartbeat, coma (loss of consciousness for a period of time).


Reference: https://medlineplus.gov/druginfo/meds/a694020.html

Mirtazapine (Remeron ®)

IMPORTANT WARNING:

A small number of children, teenagers, and young adults (up to 24 years of age) who took antidepressants ('mood elevators') such as mirtazapine during clinical studies became suicidal (thinking about harming or killing oneself or planning or trying to do so). Children, teenagers, and young adults who take antidepressants to treat depression or other mental illnesses may be more likely to become suicidal than children, teenagers, and young adults who do not take antidepressants to treat these conditions. However, experts are not sure about how great this risk is and how much it should be considered in deciding whether a child or teenager should take an antidepressant. Children younger than 18 years of age should not normally take mirtazapine, but in some cases, a doctor may decide that mirtazapine is the best medication to treat a child's condition.

You should know that your mental health may change in unexpected ways when you take mirtazapine or other antidepressants even if you are an adult over 24 years of age. You may become suicidal, especially at the beginning of your treatment and any time that your dose is increased or decreased. You, your family, or your caregiver should call your doctor right away if you experience any of the following symptoms: new or worsening depression; thinking about harming or killing yourself, or planning or trying to do so; extreme worry; agitation; panic attacks; difficulty falling asleep or staying asleep; aggressive behavior; irritability; acting without thinking; severe restlessness; and frenzied abnormal excitement. Be sure that your family or caregiver knows which symptoms may be serious so they can call the doctor if you are unable to seek treatment on your own. Your healthcare provider will want to see you often while you are taking mirtazapine, especially at the beginning of your treatment. Be sure to keep all appointments for office visits with your doctor.

The doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with mirtazapine. Read the information carefully and ask your doctor or pharmacist if you have any questions. You also can obtain the Medication Guide from the FDA website: http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm.

No matter what your age, before you take an antidepressant, you, your parent, or your caregiver should talk to your doctor about the risks and benefits of treating your condition with an antidepressant or with other treatments. You should also talk about the risks and benefits of not treating your condition. You should know that having depression or another mental illness greatly increases the risk that you will become suicidal. This risk is higher if you or anyone in your family has or has ever had bipolar disorder (mood that changes from depressed to abnormally excited) or mania (frenzied, abnormally excited mood) or has thought about or attempted suicide. Talk to your doctor about your condition, symptoms, and personal and family medical history. You and your doctor will decide what type of treatment is right for you.

What special precautions should I follow?

Before taking mirtazapine, tell your doctor and pharmacist if you are allergic to mirtazapine, any other medications, or any of the ingredients in mirtazapine tablets or disintegrating tablets. Ask your doctor or pharmacist for a list of the ingredients. Tell your doctor if you are taking a monoamine oxidase (MAO) inhibitor such as isocarboxazid (Marplan), linezolid (Zyvox), methylene blue, phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar), and tranylcypromine (Parnate) or if you have stopped taking an MAO inhibitor within the past 14 days. Your doctor will probably tell you not to take mirtazapine. If you stop taking mirtazapine, you should wait at least 14 days before you start to take an MAO inhibitor. Tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, and nutritional supplements you are taking or plan to take. Be sure to mention any of the following: anticoagulants ('blood thinners') such as warfarin (Coumadin, Jantoven); antidepressants such as amitriptyline (Elavil), amoxapine (Asendin), clomipramine (Anafranil), desipramine (Norpramin), doxepin, imipramine (Tofranil), nortriptyline (Aventyl, Pamelor), protriptyline (Vivactil), and trimipramine (Surmontil); certain antifungals such as ketoconazole (Nizoral); buspirone; carbamazepine (Carbatrol, Epitol, Equetro, Tegretol, other); cimetidine (Tagamet); diazepam (Valium); erythromycin (E-mycin, Erythrocin); fentanyl (Abstral, Actiq, Fentora, Onsolis, others); lithium (Eskalith, Lithobid); medications for migraine headaches such as almotriptan (Axert), eletriptan (Relpax), frovatriptan (Frova), naratriptan (Amerge), rizatriptan (Maxalt), sumatriptan (Imitrex), and zolmitriptan (Zomig); certain medications to treat HIV; medications for anxiety and seizures; nefazodone; phenytoin (Dilantin); rifampin (Rimactane, Rifadin, in Rifater, in Rifamate); sedatives; selective serotonin reuptake inhibitors (SSRIs) such as citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem), fluvoxamine (Luvox), paroxetine (Paxil, Pexeva), and sertraline (Zoloft); selective serotonin and norepinephrine reuptake inhibitors (SNRIs) such as desvenlafaxine (Pristiq), duloxetine (Cymbalta), and venlafaxine (Effexor); sleeping pills; tramadol (Ultram); and tranquilizers. Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Tell your doctor what herbal products you are taking, especially St. John's wort and tryptophan. Tell your doctor if you have or have ever had a heart attack, low blood pressure, heart, kidney, or liver disease, or high cholesterol.​ ​

ell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking mirtazapine, call your doctor. If you are having surgery, including dental surgery, tell the doctor or dentist that you are taking mirtazapine. You should know that this medication may make you drowsy. Do not drive a car or operate machinery until you know how this medication affects you. Remember that alcohol can add to the drowsiness caused by this medication. If you have phenylketonuria (PKU, an inherited condition in which a special diet must be followed to prevent damage to your brain that can cause severe intellectual disability), you should know that the orally disintegrating tablets contain aspartame that forms phenylalanine. You should know that mirtazapine may cause angle-closure glaucoma (a condition where the fluid is suddenly blocked and unable to flow out of the eye causing a quick, severe increase in eye pressure which may lead to a loss of vision). Talk to your doctor about having an eye examination before you start taking this medication. If you have nausea, eye pain, changes in vision, such as seeing colored rings around lights, and swelling or redness in or around the eye, call your doctor or get emergency medical treatment right away.

What side effects can this medication cause?

Mirtazapine may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

• drowsiness​​
• dizziness
  
• anxiety
  
• confusion​​
• increased weight and appetite​​
• dry mouth​​
• constipation​
• nausea​​
• vomiting
  

Some side effects can be serious. If you experience any of the following symptoms or those listed in the IMPORTANT WARNING or SPECIAL PRECAUTIONS section, call your doctor immediately or get emergency medical treatment:

• flu-like symptoms, fever, chills, sore throat, mouth sores, or other signs of infection de garganta, ampollas en la boca u otros signos de infección
  
• chest pain
  
• fast heartbeat​​
• seizures
  

Mirtazapine may cause other side effects. Call your doctor if you have any unusual problems while you are taking this medication. If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online ( (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

In case of emergency/overdose

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call mergency services at 911.

Reference: https://medlineplus.gov/druginfo/meds/a697009.html

Sertraline (Zoloft ®)

IMPORTANT WARNING:

A small number of children, teenagers, and young adults (up to 24 years of age) who took antidepressants ('mood elevators') such as sertraline during clinical studies became suicidal (thinking about harming or killing oneself or planning or trying to do so). Children, teenagers, and young adults who take antidepressants to treat depression or other mental illnesses may be more likely to become suicidal than children, teenagers, and young adults who do not take antidepressants to treat these conditions. However, experts are not sure about how great this risk is and how much it should be considered in deciding whether a child or teenager should take an antidepressant. You should know that your mental health may change in unexpected ways when you take sertraline or other antidepressants even if you are an adult over 24 years of age. You may become suicidal, especially at the beginning of your treatment and any time that your dose is increased or decreased. You, your family, or your caregiver should call your doctor right away if you experience any of the following symptoms: new or worsening depression; thinking about harming or killing yourself, or planning or trying to do so; extreme worry; agitation; panic attacks; new or worsening anxiety; difficulty falling asleep or staying asleep; aggressive behavior; irritability; acting without thinking; severe restlessness; and frenzied abnormal excitement. Be sure that your family or caregiver knows which symptoms may be serious so they can call the doctor if you are unable to seek treatment on your own. Your healthcare provider will want to see you often while you are taking sertraline, especially at the beginning of your treatment. Be sure to keep all appointments for office visits with your doctor.

The doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with sertraline. Read the information carefully and ask your doctor or pharmacist if you have any questions. You also can obtain the Medication Guide from the FDA website: http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm.

No matter what your age, before you take an antidepressant, you, your parent, or your caregiver should talk to your doctor about the risks and benefits of treating your condition with an antidepressant or with other treatments. You should also talk about the risks and benefits of not treating your condition. You should know that having depression or another mental illness greatly increases the risk that you will become suicidal. This risk is higher if you or anyone in your family has or has ever had bipolar disorder (mood that changes from depressed to abnormally excited) or mania (frenzied, abnormally excited mood) or has thought about or attempted suicide. Talk to your doctor about your condition, symptoms, and personal and family medical history. You and your doctor will decide what type of treatment is right for you.

What special precautions should I follow?

Before taking sertraline, tell your doctor and pharmacist if you are allergic to sertraline, any other medications, any of the ingredients in sertraline preparations, or latex (found in the dropper for the concentrate). Before taking sertraline liquid concentrate, tell your doctor if you are allergic to latex. Ask your pharmacist for a list of the ingredients. Tell your doctor if you are taking monoamine oxidase (MAO) inhibitors including isocarboxazid (Marplan), linezolid (Zyvox), methylene blue, phenelzine (Nardil), selegiline (Emsam, Zelapar), and tranylcypromine (Parnate), or have stopped taking them within the past 2 weeks, or if you are taking pimozide (Orap). Your doctor will probably tell you not to take sertraline. If you stop taking sertraline, you should wait at least 2 weeks before you start to take an MAO inhibitor. Do not take disulfiram (Antabuse) while taking sertraline oral concentrate. Tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: amiodarone (Nexterone, Pacerone); amphetamines; anticoagulants ('blood thinners') such as warfarin (Coumadin, Jantoven) and heparin; aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen (Advil, Motrin) and naproxen (Aleve, Naprosyn); atomoxetine (Straterra); buspirone, chlorpromazine; clopidogrel (Plavix), dextromethorphan (found in many cough medications; in Nuedexta); fentanyl (Actiq, Fentora, Lazanda, others), droperidol (Inapsine); erythromycin (E.E.S, Eryc, Ery-tab, others); fosphenytoin (Cerebyx); iloperidone (Fanapt); lithium (Lithobid); medications for anxiety, mental illness, Parkinson's disease, and seizures; medications for irregular heartbeat such as flecainide and propafenone (Rythmol); metoprolol (Lopressor, Toprol XL); medications for migraine headaches such as almotriptan (Axert), eletriptan (Relpax), frovatriptan (Frova), naratriptan (Amerge), rizatriptan (Maxalt), sumatriptan (Imitrex), and zolmitriptan (Zomig); mefloquine; methadone (Dolophine, Methadose); moxifloxacin (Avelox); nebivolol (Bystolic, in Byvalson); pentamidine (Nebupent, Pentam); perphenazine; phenytoin (Dilantin, Phenytek); procainamide; quinidine (in Nuedexta); sedatives; sleeping pills; other selective serotonin-reuptake inhibitors such as citalopram (Celexa), fluoxetine (Prozac), or fluvoxamine (Luvox); serotonin–norepinephrine reuptake inhibitors (SNRI) medications such as desvenlafaxine (Khedezla, Pristiq), duloxetine (Cymbalta), levomilnacipran (Fetzima), and venlafaxine; sotalol (Betapace, Sotylize); tacrolimus (Astagraf, Envarsus XR, Prograf); thioridazine; tolterodine (Detrol); tramadol (Conzip, Qdolo, Ultram); tranquilizers; tricyclic antidepressants ('mood elevators') such as amitriptyline, amoxapine, clomipramine (Anafranil), desipramine (Norpramin), doxepin, imipramine (Tofranil), nortriptyline (Pamelor), protriptyline (Vivactil), or trimipramine; or ziprasidone (Geodon). Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with sertraline, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.​

Tell your doctor what herbal products and nutritional supplements you are taking, especially St. John's wort and tryptophan. Tell your doctor if you have recently had a heart attack or stroke or if you have high blood pressure, bleeding problems, a low level of sodium in your blood and if you have or have ever had seizures or liver, kidney, or heart disease. Tell your doctor if you are pregnant, especially if you are in the last few months of your pregnancy, or if you plan to become pregnant or are breastfeeding. If you become pregnant while taking sertraline, call your doctor. Sertraline may cause problems in newborns following delivery if it is taken during the last months of pregnancy. You should know that sertraline may make you drowsy. Do not drive a car or operate machinery until you know how this medication affects you. Ask your doctor about the safe use of alcoholic beverages while you are taking sertraline. You should know that sertraline may cause angle-closure glaucoma (a condition where the fluid is suddenly blocked and unable to flow out of the eye causing a quick, severe increase in eye pressure which may lead to a loss of vision). Talk to your doctor about having an eye examination before you start taking this medication. If you have nausea, eye pain, changes in vision, such as seeing colored rings around lights, and swelling or redness in or around the eye, call your doctor or get emergency medical treatment right away.

What side effects can this medication cause?

Sertraline may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

• nausea
  
• diarrhea
  
• constipation​
• vomiting​​
• difficulty falling asleep or staying asleep​​
• dry mouth​​
• heartburn​​
• decreased appetite​
• weight changes​​
• dizziness​​
• excessive tiredness​
• headache​​
• nervousness​
• uncontrollable shaking of a part of the body​​
• sexual problems in males; decreased sex drive, inability to get or keep an erection, or delayed or absent ejaculation​​
• sexual problems in females; decreased sex drive, or delayed orgasm or unable to have an orgasm​​
• excessive sweating
  

Some side effects can be serious. If you experience any of the following symptoms or those listed in the IMPORTANT WARNING or SPECIAL PRECAUTIONS section, call your doctor immediately:

• seizures
  
• abnormal bleeding or bruising
  
• agitation, hallucinations, fever, sweating, confusion, fast heartbeat, shivering, severe muscle stiffness or twitching, loss of coordination, nausea, vomiting, or diarrhea
  
• headache, weakness, unsteadiness, confusion, or memory problems​​
• rash​​
• hives​​
• swelling​​
• difficulty breathing
  

La sertralina puede disminuir el apetito y causar pérdida de peso en los niños. El médico de su hijo observará atentamente su crecimiento. Hable con el médico de su hijo si tiene inquietudes sobre el crecimiento o el peso de su hijo mientras toma este medicamento. Hable con el médico de su hijo sobre los riesgos de darle sertralina a su hijo. La sertralina puede ocasionar otros efectos secundarios. Llame a su médico si tiene algún problema inusual mientras toma este medicamento. Si experimenta un efecto secundario grave, usted o su médico pueden enviar un informe en línea al programa MedWatch Adverse Event Reporting de la Administración de Alimentos y Medicamentos (FDA) (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

In case of emergency/overdose

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.
 
Symptoms of overdose may include drowsiness, agitation, hallucinations, fever, sweating, confusion, fast heartbeat, shivering, severe muscle stiffness or twitching, loss of coordination, nausea, vomiting, or diarrhea, excessive tiredness, dizziness, agitation, mania, seizures, loss of consciousness, dizziness, rapid, irregular, or pounding heartbeat.

Reference https://medlineplus.gov/druginfo/meds/a697048.html